Troubleshooting Inconsistent Engraftment in a Murine Leukemia Model
Our team is running a disseminated AML xenograft model (luciferase-tagged cell line, NSG mice, IV injection) to support lead compound efficacy studies. Over the last three cohorts, engraftment has been inconsistent: bioluminescence signal is present but highly variable between animals within the same cohort & roughly 30% of animals show no detectable engraftment by day […]
Dr. Richard Jayaraj
Neuroscientist with over 15 years of international research experience across four countries, specializing in multi-disciplinary pre-clinical and clinical projects spanning in silico, in vitro, and in vivo disease models and human biomarkers. I started my research journey from a humble background, without access to sophisticated labs or resources, yet went on to complete my PhD […]
Jenna Montgomery Harvey, PhD
I am a neuroscience drug discovery scientist with more than 15 years of experience spanning neurophysiology, neurodegenerative disease research, translational biology, and therapeutic development. Throughout my career, I have worked across academia, biotechnology, and pharmaceutical research, advancing programmes from target identification and validation through candidate nomination and early preclinical development. In recent years, I have […]
Sudipta Dutta
A growth-oriented researcher with over 10 years of experience in endocrinology, cell and molecular biology, in vivo studies. Ability to learn new techniques; experienced in data analysis, data interpretation, data management, and solving complex problems. Strong oral and written communication skills, cross-functional team collaboration and ability to present scientific data and concepts as evidenced by […]
Sara M. Elkashef, PhD, PharmD
Tumor biology and oncology drug-discovery leader with more than 14 years of experience advancing cancer therapeutic programs across tumor-intrinsic biology, target discovery and validation, oncogenic signaling, cancer genomics-informed research, in vitro and in vivo oncology models, precision oncology, immuno-oncology, radiopharmaceuticals, biologics, small molecules, and gene-editing platforms. Proven record leading discovery and translational studies that define […]
Khushbukhat Khan
Hello — I’m Dr. Khushbukhat Khan, PhD in Cancer Biology. I help biotech companies, health-tech startups, and research teams translate cancer biology research into clinically relevant and commercially viable products, with a focus on early-stage development, translational strategy, and evidence generation. With 5+ years of experience across cancer biology, bioinformatics, and translational research, I work […]