Troubleshooting Inconsistent Engraftment in a Murine Leukemia Model
Our team is running a disseminated AML xenograft model (luciferase-tagged cell line, NSG mice, IV injection) to support lead compound efficacy studies. Over the last three cohorts, engraftment has been inconsistent: bioluminescence signal is present but highly variable between animals within the same cohort & roughly 30% of animals show no detectable engraftment by day […]