Director of Pharmacology with over 13 years of experience in preclinical assessment, pharmacology, and pharmaceutical drug development. Proven track record of leading successful drug discovery projects, managing multidisciplinary teams, and achieving tight deadlines in fast-paced environments. Expert in identifying innovative therapeutics and driving projects from discovery to clinical trials. Skilled in fundraising and budget allocation, securing significant funding for groundbreaking programs. Demonstrated expertise in regulatory submissions, ensuring smooth transitions from preclinical to clinical stages. Recognized for first-author publications in top scientific journals and multiple internationally acclaimed awards. Currently leading a pharmacology team at Jubilant Draximage, driving the development of new genetic targets and successful FDA interactions
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Led Pharmacology Team: Successfully managed a team and oversaw more than 10 projects from discovery campaign initiation to lead candidate selection. Designed and executed experiments for preclinical in vitro and in vivo pharmacological studies, culminating in the creation of reports and regulatory affairs documents that facilitated several successful FDA meetings.
Strategic Development: Developed and implemented strategies to identify unmet needs and demonstrate the value and affordability of over 20 new genetic targets for precision therapy and diagnostics. Collaborated with multidisciplinary teams to design innovative molecules for various disease targets, securing funding for two new programs and initiating their preclinical studies.
Project and Budget Management: Provided leadership in managing projects, budgets, and timelines. Collaborated closely with external laboratories and CROs to design and test new ligands for cutting-edge projects, ensuring rigorous quality control throughout the process.
Data-Driven Decision Making: Conducted thorough literature reviews and attended conferences to gain insights and provide feedback on leveraging real-world evidence for product development, informing strategic decision-making in drug development.
Regulatory Strategy and Support: Collaborated with R&D, regulatory affairs, and clinical teams to develop Phase I strategies and provided scientific support for FDA and other regulatory agency filings, ensuring seamless transitions from preclinical to clinical stages.
Fundraising and Stakeholder Engagement: Led strategic and technical discussions with R&D teams and external/internal stakeholders. Successfully spearheaded fundraising campaigns, raising over $500k, demonstrating strong negotiation and influencing skills.
Strategic Assessment and Project Leadership: Critically assessed drivers and barriers for successful implementation of new molecules in routine care. Spearheaded the conception of experiments, preparation of proposals, and data analysis for the development of the gene editing platform, leading to securing funding for proof-of-concept (PoC) projects and the submission of publications.
Mentorship and Team Management: Mentored, trained, and managed junior technical team members. Wrote and reviewed standard operating procedures (SOPs) to ensure smooth transfer of knowledge and consistent experimental execution. Fostered a continuous improvement mindset within the organization, focusing on optimized workflows and team spirit.
Data Interpretation and Communication: Interpreted, presented, and delivered results effectively within a team environment and to external stakeholders.
Collaborative Project Leadership: Led team-wide projects in collaboration with academic and industrial institutions, ensuring successful project progress and the establishment of external collaborations.
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Assay Development and Optimization: Led assay development on a drug discovery project and optimized two novel high-throughput cellular assays for small-molecule inhibitors of a Polysialyltransferase enzyme. One assay resulted in a successful Wellcome Trust grant with Argenta Discovery Ltd. (a division of Charles River) and is used to identify a novel anti-metastatic drug.
Drug Optimization and Mechanism Investigation: Performed hit-to-lead optimization of novel drugs, evaluated drug efficacy and selectivity, and investigated mechanisms of action.
Clinical Assay Development: Developed clinical assays to evaluate Polysialic acid in patients’ serum as a peripheral biomarker.
Publications and Scientific Contribution: Published four papers on the role of Polysialyltransferase enzyme in neuroblastoma migration capacity and assays developed to analyze enzyme activity.
Conference Presentations and Recognition: Awarded the BACR travel grant and presented research at several conferences.
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