Profile of Sara M. Elkashef

Sara M. Elkashef Head of Pharmacology | Leading Innovative Preclinical Studies | Expert in Translating Research to Clinical Success
14 years experience 0 projects worked Canada
Academic JournalsCareer ConsultationDrug DevelopmentDrug DiscoveryGene Editing (CRISPR, TALEN)Good Laboratory Practices (GLP)Immuno-OncologyImmunologyIn VitroIn VivoMedical DevicesMedical ImagingOncologyPharmacologyPharmacyPreclinicalRadiologyRegulatory AffairsTargeted Drug Delivery

Head of Pharmacology with over 14 years of experience in preclinical assessment, pharmacology, and pharmaceutical drug development. Proven track record of leading successful drug discovery projects, managing multidisciplinary teams, and achieving tight deadlines in fast-paced environments. Expert in identifying innovative therapeutics and driving projects from discovery to clinical trials. Skilled in fundraising and budget allocation, securing significant funding for groundbreaking programs. Demonstrated expertise in regulatory submissions, ensuring smooth transitions from preclinical to clinical stages. Recognized for first-author publications in top scientific journals and multiple internationally acclaimed awards. Currently leading a pharmacology team at Jubilant Draximage, driving the development of new genetic targets and successful FDA interactionsHead of Pharmacology with over 13 years of experience in preclinical assessment, pharmacology, and pharmaceutical drug development. Proven track record of leading successful drug discovery projects, managing multidisciplinary teams, and achieving tight deadlines in fast-paced environments. Expert in identifying innovative therapeutics and driving projects from discovery to clinical trials. Skilled in fundraising and budget allocation, securing significant funding for groundbreaking programs. Demonstrated expertise in regulatory submissions, ensuring smooth transitions from preclinical to clinical stages. Recognized for first-author publications in top scientific journals and multiple internationally acclaimed awards. Currently leading a pharmacology team at Jubilant Draximage, driving the development of new genetic targets and successful FDA interactions

Work History (0)

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Work Experiences

  • Senior Postdoctoral Fellow in Tumor Biomarkers and Precision Medicine

    University of Texas

    August 2016 - August 2018

    Precision Medicine Research: Led precision medicine evidence generation studies from concept development through publication in peer-reviewed journals. Published a first-author paper in Cancer Cell (Impact Factor 31.74) and a co-authored paper in Cell Chemical Biology (Impact Factor 7.7). Presented research at international conferences including ASH and AACR.

    Epigenetic Research in Leukemia: Led a project investigating novel epigenetic changes in molecular pathways in leukemia. Developed sophisticated in vitro and in vivo genetic models using CRISPR-Cas9 technology and site-directed mutagenesis, providing evidence for the efficacy of an epigenetic modulator drug in eradicating tumors within specific patient subsets.

    Data Analysis and Communication: Analyzed complex data sets and translated results to test scientific hypotheses. Effectively communicated research findings to team members and external stakeholders at leading scientific meetings.

    Collaboration Management: Arranged and managed collaborations with multiple partners including clinicians, pathologists, and core facilities, ensuring successful project outcomes.
    Team Leadership and Training: Trained and supervised research associates, junior post-docs, and technicians, fostering a collaborative and productive research environment.

    Award Recognition: Received the American Society of Hematology achievement award for outstanding contributions to hematology research.

  • Senior Postdoctoral Researcher in Precision Oncology and Team Leadership

    University Health Network

    January 2019 - October 2022

    Preclinical Studies and Tumor-Agnostic Treatments: Led preclinical studies investigating tumor-agnostic treatments targeting tumor-intrinsic pathways and mechanisms of brain tumor immune resistance.

    Executed complex cell-based in vitro and in vivo assays to identify novel genetic biomarkers for immunotherapy.

    Project Management: Strategically managed projects, including designing, selecting, and validating study models, executing laboratory experiments, and managing complex resources such as paperwork, ordering, protocols, SOPs, and experimental materials.

    Data Analysis and Interpretation: Conducted comprehensive data synthesis, collection, analysis, and interpretation to drive research insights.

    Grant Writing and Publications: Wrote proposals and reports, presented projects at conferences, and successfully secured a $100,000 grant from the Brain Tumour Foundation of Canada. Utilizing this grant, currently in the process of publishing two first-author papers.

  • Senior Research Associate in Gene Editing and Project Management

    Specific Biologics

    October 2021 - October 2022

    Strategic Assessment and Project Leadership: Critically assessed drivers and barriers for successful implementation of new molecules in routine care. Spearheaded the conception of experiments, preparation of proposals, and data analysis for the development of the gene editing platform, leading to securing funding for proof-of-concept (PoC) projects and the submission of publications.

    Mentorship and Team Management: Mentored, trained, and managed junior technical team members. Wrote and reviewed standard operating procedures (SOPs) to ensure smooth transfer of knowledge and consistent experimental execution. Fostered a continuous improvement mindset within the organization, focusing on optimized workflows and team spirit.

    Data Interpretation and Communication: Interpreted, presented, and delivered results effectively within a team environment and to external stakeholders.
    Collaborative Project Leadership: Led team-wide projects in collaboration with academic and industrial institutions, ensuring successful project progress and the establishment of external collaborations.

  • Principal Scientist | Head of Pharmacology team

    Jubilant Radiopharma

    October 2021 - Now

    Led Pharmacology Team: Successfully managed a team and oversaw more than 10 projects from discovery campaign initiation to lead candidate selection. Designed and executed experiments for preclinical in vitro and in vivo pharmacological studies, culminating in the creation of reports and regulatory affairs documents that facilitated several successful FDA meetings.

    Strategic Development: Developed and implemented strategies to identify unmet needs and demonstrate the value and affordability of over 20 new genetic targets for precision therapy and diagnostics. Collaborated with multidisciplinary teams to design innovative molecules for various disease targets, securing funding for two new programs and initiating their preclinical studies.

    Project and Budget Management: Provided leadership in managing projects, budgets, and timelines. Collaborated closely with external laboratories and CROs to design and test new ligands for cutting-edge projects, ensuring rigorous quality control throughout the process.

    Data-Driven Decision Making: Conducted thorough literature reviews and attended conferences to gain insights and provide feedback on leveraging real-world evidence for product development, informing strategic decision-making in drug development.

    Regulatory Strategy and Support: Collaborated with R&D, regulatory affairs, and clinical teams to develop Phase I strategies and provided scientific support for FDA and other regulatory agency filings, ensuring seamless transitions from preclinical to clinical stages.

    Fundraising and Stakeholder Engagement: Led strategic and technical discussions with R&D teams and external/internal stakeholders. Successfully spearheaded fundraising campaigns, raising over $500k, demonstrating strong negotiation and influencing skills.Led Pharmacology Team: Successfully managed a team and oversaw more than 10 projects from discovery campaign initiation to lead candidate selection. Designed and executed experiments for preclinical in vitro and in vivo pharmacological studies, culminating in the creation of reports and regulatory affairs documents that facilitated several successful FDA meetings. Strategic Development: Developed and implemented strategies to identify unmet needs and demonstrate the value and affordability of over 20 new genetic targets for precision therapy and diagnostics. Collaborated with multidisciplinary teams to design innovative molecules for various disease targets, securing funding for two new programs and initiating their preclinical studies. Project and Budget Management: Provided leadership in managing projects, budgets, and timelines. Collaborated closely with external laboratories and CROs to design and test new ligands for cutting-edge projects, ensuring rigorous quality control throughout the process. Data-Driven Decision Making: Conducted thorough literature reviews and attended conferences to gain insights and provide feedback on leveraging real-world evidence for product development, informing strategic decision-making in drug development. Regulatory Strategy and Support: Collaborated with R&D, regulatory affairs, and clinical teams to develop Phase I strategies and provided scientific support for FDA and other regulatory agency filings, ensuring seamless transitions from preclinical to clinical stages. Fundraising and Stakeholder Engagement: Led strategic and technical discussions with R&D teams and external/internal stakeholders. Successfully spearheaded fundraising campaigns, raising over $500k, demonstrating strong negotiation and influencing skills.

Certification

  • Pharmacy Degree

    Mansoura University

    June 2005 - July 2010

    Grade: Distinction (GPA 4)

Education

  • MSc. Cancer Pharmacology

    University of Bradford

    January 2011 - January 2012

    Grade: Distinction Grade: Distinction
    •Worked on analyzing the pharmacokinetics/pharmacodynamics of a novel vascular disrupting agent, which is due to begin phase I clinical trial. My work in this area produced valuable data for preclinical development.
    •Earned Master’s degree with high distinction

  • PhD Pharmacology and Drug Discovery

    University of Bradford

    January 2013 - July 2016

    Assay Development and Optimization: Led assay development on a drug discovery project and optimized two novel high-throughput cellular assays for small-molecule inhibitors of a Polysialyltransferase enzyme. One assay resulted in a successful Wellcome Trust grant with Argenta Discovery Ltd. (a division of Charles River) and is used to identify a novel anti-metastatic drug.
    Drug Optimization and Mechanism Investigation: Performed hit-to-lead optimization of novel drugs, evaluated drug efficacy and selectivity, and investigated mechanisms of action.
    Clinical Assay Development: Developed clinical assays to evaluate Polysialic acid in patients’ serum as a peripheral biomarker.
    Publications and Scientific Contribution: Published four papers on the role of Polysialyltransferase enzyme in neuroblastoma migration capacity and assays developed to analyze enzyme activity.
    Conference Presentations and Recognition: Awarded the BACR travel grant and presented research at several conferences.